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Published on:
11-May-2006
E-books
Anti malaria Drugs
Author:
J. Ghosh
This excerpt (pp. 78-84 of Chapter 7, “Antibacterial Drugs,” in Fundamental Concepts of Applied Chemistry) introduces sulphonamides and antibiotics. It traces sulphonamides from Domagk’s 1930 prontosil, which is reduced in the body to active sulphanilamide. It covers their amphoteric properties, characteristic reactions, structure-activity relationships, and mechanism as PABA antimetabolites that block bacterial folic acid synthesis. Syntheses, uses, and adverse effects are given for sulph... see more